Izervay: FDA Approved Breakthrough for Geographic Atrophy
For the estimated 11 million Americans living with age-related macular degeneration (AMD), geographic atrophy (GA) can be a daunting reality. Approximately 20% of patients with AMD will develop geographic atrophy, an advanced form of dry AMD characterized by the progressive loss of healthy retinal tissue over time. The gradual loss of vision in the central part of the retina can significantly impact patients’ quality of life.
Until earlier this year, there were no Food and Drug Administration (FDA) approved treatments available to patients with geographic atrophy. In February 2023, Syfovre (pegcetacoplan) became the first FDA-approved treatment for geographic atrophy, and now, the FDA has approved a second medication, Izervay (avacincaptad pegol).
These medications were designed to target and neutralize genetic changes associated with the “complement cascade”, a part of the immune system responsible for regulating inflammation and immune response. In geographic atrophy, an overactive complement system can contribute to the destruction of retinal cells, exacerbating the condition.
Clinical studies have shown that intravitreal injections of these medications approximately every 1-2 months are effective at reducing the rate of enlargement of areas of atrophy, and that this effect increases with longer treatment duration.
Syfovre and Izervay aim to slow down the progression of geographic atrophy and offer a ray of hope for preserving central vision in AMD patients.
What This Means for Patients
The approval of Syfovre and Izervay represents a groundbreaking moment in the field of ophthalmology. Our retina specialists are excited to offer these breakthrough treatments to Central Texas patients with geographic atrophy. As with any medical treatment, it's essential to consult with your physician to explore whether these treatments are a suitable option for you.
To learn more about treatment for all forms of AMD, please feel free to discuss with an Austin Retina Associates physician, call Austin Retina Associates at 800-252-8259, or request an appointment online at one of our 14 Central Texas locations.